CobaltMaghrebV1, Main, Exploration, bibRecord, 000445

Propolis attenuates cobalt induced-nephrotoxicity in adult rats and their progeny

Identifieur interne : 000445 ( Main/Exploration ); précédent : 000444; suivant : 000446

Propolis attenuates cobalt induced-nephrotoxicity in adult rats and their progeny

Auteurs : El Mouldi Garoui [Tunisie] ; Afef Troudi [Tunisie] ; Hamadi Fetoui [Tunisie] ; Nejla Soudani [Tunisie] ; Tahia Boudawara [Tunisie] ; Najiba Zeghal [Tunisie]

Source :

Experimental and toxicologic pathology : (Print) [ 0940-2993 ] ; 2012.

RBID : Pascal:12-0441031

Descripteurs français

Pascal (Inist)
- Propolis, Cobalt, Toxicité, Néphrotoxicité, Animal adulte, Rat, Descendance, Chlorure de cobalt, Gestation, Allaitement, Antioxydant, Propriété, Anatomopathologie.
Wicri :
- topic : Cobalt.

English descriptors

KwdEn :
- Adult animal, Anatomic pathology, Antioxidant, Breast feeding, Cobalt, Cobalt chloride, Nephrotoxicity, Pregnancy, Progeny, Properties, Propolis, Rat, Toxicity.

Abstract

The aim of this study was to evaluate the biochemical changes in cobalt-exposed rats and to investigate the potential role of Tunisian propolis against the cobalt-induced renal damages. Twenty-four pregnant Wistar rats were divided into four groups and were treated as follows: group 1 (control) received distilled water; group 2 received 350 ppm of CoCl₂ in drinking water; group 3 received 350 ppm CoCl₂ in drinking water and a propolis-supplemented diet (1 g/100 g of diet); group 4 received a propolis-supplemented diet (1 g/100 g of diet) without cobalt. In the cobalt group, a significant decrease in body, absolute and relative weights was noted when compared to controls. The administration of cobalt to pregnant rats from the 14th day of pregnancy until day 14 after delivery resulted in an increased level of renal malondialdehyde, a decreased renal content of glutathione and antioxidant enzyme activities such as superoxide dismutase, catalase and glutathione peroxidase in lactating rats and their pups. A statistically significant increase in plasma urea and creatinine serum levels was seen in treated female rats and their pups. Histopathologically, the cobalt-administration induced degenerative changes in the kidney of lactating rats and their pups. When compared with cobalt-treated rats, those receiving the propolis supplementation (along with cobalt-treatment) had lower malondialdehyde levels, higher antioxidant activities and the cobalt-related histopathological changes in the kidneys were at lower severity.Our results suggested that the propolis might be a potential candidate agent against cobalt-induced nephrotoxicity in adult and juvenile rats when administered to female rats during the late pregnancy and the early postnatal period.

Affiliations:

Tunisie

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Le document en format XML

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<term>Nephrotoxicity</term>
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<front><div type="abstract" xml:lang="en">The aim of this study was to evaluate the biochemical changes in cobalt-exposed rats and to investigate the potential role of Tunisian propolis against the cobalt-induced renal damages. Twenty-four pregnant Wistar rats were divided into four groups and were treated as follows: group 1 (control) received distilled water; group 2 received 350 ppm of CoCl<sub>2</sub>
 in drinking water; group 3 received 350 ppm CoCl<sub>2</sub>
 in drinking water and a propolis-supplemented diet (1 g/100 g of diet); group 4 received a propolis-supplemented diet (1 g/100 g of diet) without cobalt. In the cobalt group, a significant decrease in body, absolute and relative weights was noted when compared to controls. The administration of cobalt to pregnant rats from the 14th day of pregnancy until day 14 after delivery resulted in an increased level of renal malondialdehyde, a decreased renal content of glutathione and antioxidant enzyme activities such as superoxide dismutase, catalase and glutathione peroxidase in lactating rats and their pups. A statistically significant increase in plasma urea and creatinine serum levels was seen in treated female rats and their pups. Histopathologically, the cobalt-administration induced degenerative changes in the kidney of lactating rats and their pups. When compared with cobalt-treated rats, those receiving the propolis supplementation (along with cobalt-treatment) had lower malondialdehyde levels, higher antioxidant activities and the cobalt-related histopathological changes in the kidneys were at lower severity.Our results suggested that the propolis might be a potential candidate agent against cobalt-induced nephrotoxicity in adult and juvenile rats when administered to female rats during the late pregnancy and the early postnatal period.</div>
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Serveur d'exploration sur le cobalt au Maghreb

Propolis attenuates cobalt induced-nephrotoxicity in adult rats and their progeny

Propolis attenuates cobalt induced-nephrotoxicity in adult rats and their progeny

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri